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Conférence grand public
Mardi 25 Février
Conférence grand public par Bernard Nordlinger à l’Espace des Sciences, 20h30
Santé et Intelligence Artificielle
Programme
Le colloque se déroule au Couvent des Jacobins du 26 au 28 février 2020.
Wednesday, February 26
13h30 Welcome address
Session 1 – New frontiers in hepatology
- 14h00 Human liver organoids to study gene function, tumour modelling and cell division Benedetta Artegiani Hubrecht Institute, Developmental Biology and Stem Cell Research, Utrecht, the Netherlands
- 14h35 New frontiers in liver development: current questions on bile duct morphogenesis Frédéric Lemaigre Université Catholique de Louvain, de Duve Institute, Brussels
- 15h10 HiPSC-derived liver organoids exhibit complex polarization and mature functions Antonietta Messina, Eléanor Luce, Ulysse Pereira, Cécile Legallais, Anne Dubart-Kupperschmitt UMR_S1193 Inserm / Université Paris‐Sud, DHU Hepatinov, Paris‐Saclay, Villejuif ; Université de technologie de Compiègne, Sorbonne Université, Compiègne, France
- 15h25 Extracellular vesicles released by hepatocytes exposed to polycyclic aromatic hydrocarbons trigger apoptosis of target hepatocytes via iron Nettie van Meteren, Dimitri Gobart, Agnès Burel, Isabelle Gallais, Éric Le Ferrec, Dominique Lagadic-Gossmann, Odile Sergent Univ Rennes, Inserm, EHESP, Irset, Plate-forme MRic-TEM, Biosit, Rennes, France
15h40 Coffee break
Session 2 – Metabolism
- 16h10 Mitochondrial cholesterol in liver diseases José Fernandez-Checa Department of Cell Death and Proliferation, Institute of Biomedical Research of Barcelona and Liver Unit, Barcelona
- 16h45 NASH, think outside the liver Isabelle Leclercq Laboratory of Gastroenterology, Université Catholique de Louvain, Brussels
- 17h20 Mechanisms of drug-induced hepatic steatosis in the absence of severe mitochondrial dysfunction: investigations with 12 drugs Julien Allard, Simon Bucher, Julie Massart, Pierre-Jean Ferron, Dounia Le Guillou, Yoann Daniel, Youenn Launay, Karima Begriche, Annie Borgne-Sanchez, Bernard Fromenty INSERM, Univ Rennes, INRAE, Institut NUMECAN, Rennes, France ; HCS Pharma, Loos, France ; MITOLOGICS S.A.S. Hôpital Henri Mondor, Créteil, France
- 17h35 The pathogenesis of NAFLD: How replication stress participates to disease progression? Romain Donné, Maëva Aïnama, Pierre Cordier, Mounia Herrag, Mira Stadler, Ivan Nemazanyy, Patrick Revy, Philippe Gual, Mathias Heikenwälder, Valérie Paradis, Chantal Desdouets Centre de Recherche des Cordeliers, INSERM, Sorbonne Université ; UMR 1163, Institut Imagine ; Institut Necker Enfants Malades, Université Paris Descartes ; Mediterranean Center for Molecular Medicine C3M, Nice ; German Cancer Research Center,Heidelberg, Germany ; INSERM U773, Centre de Recherche Biomédicale Bichat‐Beaujon, Clichy, France
- 17h50 Imbalance between hepatocyte and macrophage iron distribution highlights the singularity of aceruloplasminemia in a new knockout rat model. Moussa Kenawi, Emmanuel Rouger, François Robin, Patricia Leroyer, Marie‐Laure Island, Séverine Remy, Ignacio Anegon, Pierre Brissot, Martine Ropert, Thibault Cavey, Olivier Loréal INSERM, University of Rennes, INRAE, Institut NUMECAN, Rennes, France; INSERM UMR 1064‐CRTI, TRIP facility, Nantes, France
- 18h05 Role of fatty acids in hepatic cytochrome P450 2 E1 induction: involvement in the pathogenesis of non-alcoholic steatohepatitis (NASH) related to obesity. Clémence Penhoat, Cassandra Rayer, Matthieu Franc, Bernard Fromenty, Karima Begriche Univ Rennes, Inserm, Inrae, Institut NuMeCan, Rennes, France.
- 18h20 Lkb1 is a suppressor of the amino acid-driven hepatic gluconeogenic Pierre-Alexandre Just, Sara Charawi, Raphaël Denis, Mathilde Savall, Marjorie Leduc, Jean-Pascal De Bandt, François Guillonneau, Serge Luquet,Pascale Bossard, Christine Perret INSERM, U1016, Institut Cochin ; CNRS, UMR 8104, Université Paris Descartes ; BFA, Université Paris Diderot, CNRS UMR 8251, Plateforme « Exploration Physiologique Fonctionnelle » EPF ; Plateforme Protéomique de l’Université Paris Descartes (3P5) ; Inserm, UMR-1162, Functional Genomics of Solid Tumors, Univ Paris Descartes, Univ Paris Diderot, Univ Paris 13, France
18h40 End of the day
Thursday, February 27
Session 3 – Tissue repair
- 08h30 Using single cell transcriptomics to understand the cellular and molecular mechanisms of liver fibrosis and repair Neil Henderson Wellcome Trust Senior Research Fellow in Clinical Science, Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh
- 09h05 A biliary window on liver regeneration Thierry Tordjmann INSERM U-1174, Paris-Sud University, Orsay
- 09h40 Staufen-1-mediated translational induction of netrin-1 upon hepatic inflammation Romain Barnault, Maud Michelet, Anna-Rita Redavid, Ievgeniia Chicherova, Federica Grazia Centonze, Hesso Farhan, Benjamin Gibert, Patrick Mehlen, Fabien Zoulim, Romain Parent Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR5286, Centre anticancéreux Léon Bérard, Université de Lyon, Lyon, France ; Department of Molecular Medicine, University of Oslo, Oslo, Norway.
- 09h55 Induced pluripotent stem cell-derived human cholangiocytes Eléanor Luce, Anne Dubart-Kupperschmitt INSERM/Université Paris-Saclay ; FHU Hépatinov, Villejuif, France
10h10 Coffee break
Session 4 – Cancerology 1
- 10h35 Metabolic reprograming of hepatocellular carcinomas Pascale Bossard INSERM U-1016, Institut Cochin, Paris 11h10 Deciphering the dual role of ß-catenin in hepatocellular carcinoma Violaine Moreau INSERM U-1053, University of Bordeaux 11h45 TFOX, a novel TGFβ target gene, promotes epithelial to mesenchymal transition and is associated with poor prognosis in human hepatocellular carcinoma Kevin Bévant, Gaëlle Angenard, Stefano Caruso, Matthis Desoteux, Corentin Louis, David Gilot, Jessica Zucman-Rossi, Cédric Coulouarn Inserm UMR124 NuMeCan, Univ Rennes, Rennes ; Centre de Recherche des Cordeliers, Sorbonne Universités, Inserm, Paris ; Functional Genomics of Solid Tumors, USPC, Université Paris Descartes, Université Paris Diderot, Université Paris 13, Labex Immuno-Oncology, équipe labellisée Ligue Contre le Cancer, Paris, France ; Univ Rennes, CNRS, IGDR [(Institut de génétique et développement de Rennes)]-UMR 6290, ARC Labelled team, Rennes, France 12h00 Plasticity of hepatocellular carcinoma cells across tumor progression leads to metabolic reprogramming and chemoresistance. Daniel Yoann, Savary Camille, Petitjean Kilian, Rauch Claudine, Catheline Daniel, Allard Julien, Frenot Brigitte, Burel Agnès, Bendavid Claude, Rioux Vincent, Musso Orlando, Fromenty Bernard, Cabillic Florian, Corlu Anne Inserm, Univ Rennes, INRAE, NuMeCan Institute, CHU Rennes, Rennes, France
12h15 Lunch and Poster session (authors in attendance)
Session 5 – Cancerology 2
- 14h00 Systemic therapy of cholangiocarcinoma : “to lump or to split” Juan Valle Department of Medical Oncology, Division of Cancer Sciences, University of Manchester, Manchester
- 14h35 Pathomolecular classification of Hepatocellular Carcinomas Valérie Paradis Pathology Department, Beaujon Hospital, Clichy
- 15h10 Proteomic profiling for clinical diagnosis of Hepatocellular Adenomas Cyril Dourthe, Sylvaine Di Tommaso, Jean-William Dupuy, Alexandre Brochard, Jean-Frédéric Blanc, Charles Balabaud, Paulette Bioulac-Sage, Frédéric Saltel, Anne-Aurélie Raymond Univ.Bordeaux, INSERM, UMR1053, BaRITOn Bordeaux Research in Translational Oncology ; Plateforme Oncoprot, TBM-Core US 005 ; Plateforme Protéome, Centre de Génomique Fonctionnelle ; INSERM, U1215, Neurocentre Magendie ; CHU Bordeaux Department of Hepatology and Oncology, INSERM CIC1401, Bordeaux, France
- 15h25 Role of catecholamines on hepatic cell plasticity in hepatocellular carcinoma Elise Lelou, Claudine Rauch, Hélène Dubois-Pot-Schneider, Nicolas Nesseler, Anne Corlu,Caroline Aninat INSERM U1241, NuMeCan, Univ Rennes,INRAE, CHU Rennes, Rennes, France
15h40 Coffee break and Poster session
- 16h00 CHIEF : an update Julien Edeline Department of Medical Oncology, Centre Eugene Marquis, INSERM U1241, Institut NUMECAN, Univ Rennes, France
- 16h10 HCC risk stratification in 2020: strengths of French prospective cohorts Pierre Nahon Liver Department, Jean Verdier Hospital, Bondy
- 16h45 Deleting in vivo ß-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or mesenchymal hepatoblastoma similarly to Apc loss-of-function R. Loesch, S. Caruso, S. Picard, A. Gougelet, C. Godard, J. Zucman-Rossi, M. Taketo, S. Colnot Centre de recherche des Cordeliers, Université Paris Descartes, Paris, France ; MD Anderson Cancer Center, The University of Texas, Houston, USA
- 17h00 TGF-beta-associated circular RNAs in cholangiocarcinoma: mechanisms and biomarkers Corentin Louis, Matthis Desoteux, Gaëlle Angenard, Julien Edeline, Cédric Coulouarn Inserm, Univ Rennes, NuMeCan, Department of Medical Oncology, Centre Eugene Marquis, Rennes, France.
- 17h15 Oncofetal Gene Expression is a Sign of Cell Plasticity toward an Aggressive, Cancer-Stem-Cell-Enriched Subclass of Human Hepatocellular Carcinomas Romain Désert, Lise Desquilles, Marie Sicard, Stéphanie Renaud, Natalia Nieto, Orlando Musso INSERM, Univ Rennes, INRAE, Institut NUMECAN, Rennes, France ; Department of Pathology, Department of Medicine, University of Illinois at Chicago, IL, USA
- 17h30 Challenging the antioxidant protection of β-catenin activated hepatocellular carcinomas Mathilde Savall, Nadia Senni, Christine Perret, Pascale Bossard Institut Cochin, Development Reproduction Cancer Department, Paris, France
- 17h45 Fibroblast growth factor 19 promotes tumorigenesis in genetically defined immunocompetent HCC models José Ursic-Bedoya, Carine Chavey, Lucy Meunier, Anthony Lozano, Benjamin Rivière, Eric Assenat, Urszula Hibner, Damien Grégoire Institut de Génétique Moléculaire de Montpellier, Department of hepatogastroenterology, Hepatology and Liver Transplantation Unit, Department of Pathology, Saint Eloi Hospital, University of Montpellier, CNRS, Montpellier, France
- 18h00 Divergent mutation spectrum singles out Hepatocellular Carcinoma developed in Peruvian Patients Juan Pablo Cerapio, Agnès Marchio, Eloy Ruiz, Luis Cano, Enzo Leoni, Sandro Casavilca, Eric Deharo, Anne Dejean, Stéphane Bertani, Pascal Pineau Institut Pasteur, Unité “Organisation Nucléaire et Oncogenèse”, INSERM U993 ; Sorbonne Universités, UPMC Université Paris 06, U 1241 NUMECAN, Rennes, Paris, France ; Instituto Nacional de Enfermedades Neoplásicas, Departamento de Cirugía en Abdomen ; Instituto Nacional de Enfermedades Neoplásicas, Departamento de Patologia, Banco de Tejidos Tumorales, Lima, Peru ; Hôpital Cochin, Service d’Anatomie et Cytologie Pathologiques, Paris, France ; Université de Toulouse, UPS, UMR152 PHARMADEV, IRD, Université Toulouse 3, Toulouse, France
18h15 End of the day
19h30 Dinner – Le Piccadilly, place de la Mairie
Friday, February 28
Session 6 – Virology
- 09h00 Single Cell RNA Seq to understand the biology of virus-induced hepatocellular carcinoma Thomas Baumert INSERM U-1110, HEPSYS, University of Strasbourg
- 09h35 Toward the development of a novel innate-immune stimulators against HBV/HDV infections David Durantel INSERM U-1052, Cancer Research Center of Lyon, Lyon
- 10h10 Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Océane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddary, Laura Belloni, Mirjam B. Zeisel, Massimo Levrero, Francesca Guerrieri Center for Life Nano Science, Istituto Italiano di Tecnologia ; Unit of Nonlinear Physics and Mathematical Modeling, Department of Engineering, Università Campus Bio-Medico, Roma, Italy ; Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon (CRCL), Lyon, France ; Department of Physics and Chemistry – Emilio Segre’, University of Palermo, Palermo, Italy ; Department of Internal Medicine – DMISM, Sapienza University, Rome, Italy
10h25 Coffee break
Session 7 – New opportunities and practices in hepatology 
- 10h50 Innovations in treatment of liver tumors with internal radiotherapy Etienne Garin Centre de Lutte contre le Cancer ‘’Eugène Marquis’’, INSERM U1241, Institut NUMECAN, Univ Rennes, France
- 11h25 Immunotherapy of hepatocellular carcinomas Julien Edeline Department of Medical Oncology, Centre Eugene Marquis, INSERM U1241, Institut NUMECAN, Univ Rennes, France
- 12h00 Functional rescue of an ABCB11 mutant by ivacaftor: a new targeted pharmacotherapy approach in bile salt export pump deficiency Elodie Mareux, Martine Lapalus, Rachida Amzal, Marion Almes, Tounsia Aït Slimane, Jean-Louis Delaunay, Pauline Adnot, Mauricette Collado-Hilly, Anne Davit Spraul, Isabelle Callebaut, Emmanuel Gonzales, Emmanuel Jacquemin University of Paris-Sud/Paris-Saclay, INSERM, UMR_S 1193, Hepatinov, Orsay ; Paediatric Hepatology & Paediatric Liver Transplant Department, Reference Center for Rare Paediatric Liver Diseases, Univ Paris Sud/Paris-Saclay, CHU Bicêtre, Le Kremlin-Bicêtre ; Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), UMR_S 938, Institute of Cardiometabolism and Nutrition (ICAN) ; CHU Bicêtre, Biochemistry Unit, Le Kremlin-Bicêtre, France ; Sorbonne Université, Muséum National d’Histoire Naturelle, UMR CNRS 7590, IMPMC, 75005 Paris, France
- 12h15 Identification of a proteomic signature predicting response to sorafenib in advanced hepatocellular carcinoma Caroline Toulouse, Mélanie Moreau, Sylvaine Di Tommaso, Nathalie Allain-Courtois, Jean-William Dupuy, Brigitte Le Bail, Paulette Bioulac-Sage, Jean-Frédéric Blanc, Anne-Aurélie Raymond, Frédéric Saltel Univ.Bordeaux, INSERM, UMR1053, BaRITOn Bordeaux Research in Translational Oncology ; CHU Bordeaux Department of Hepatology and Oncology, INSERM CIC1401 ; Plateforme Oncoprot, TBM-Core US 005 ; Plateforme Protéome, Centre de Génomique Fonctionnelle ; CHU Bordeaux Department of Pathology, Bordeaux, France
- 12h30 Metallomic profiles in patients with non-cirrhotic liver hepatocellular carcinoma emphasizes the link between metals and liver carcinogenic process. Luis Cano, Stéphane Bertani, Marie-Laure Island, Martine Ropert, Bruno Turlin, Olivier Loréal INSERM, Univ Rennes, INRAE, UMR1241, CHU de Rennes, Institut NuMeCan, Plateforme AEM2, Rennes ; Université de Toulouse, IRD, UPS, UMR 152 PHARMADEV, Toulouse.
- 12h45 HCC emergence in diabetic mice with NASH depends on high-fat diet and is delayed in liver exhibiting an active immune response Mélanie Simoes Eugénio, Muhammad Farooq, Sarah Dion, Christelle Devisme, Céline Raguenes-Nicol, Claire Piquet-Pellorce, Michel Samson, Marie-Thérèse Dimanche-Boitrel, Jacques Le Seyec Univ Rennes, Inserm, EHESP, Irset, UMR_S 1085, Rennes, France ; Department of Clinical Sciences, College of Veterinary and Animal Sciences, Jhang, Pakistan.
Awards : Oral Presentation and Poster
Concluding remarks, end of the meeting