Programme

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Conférence grand public

Mardi 25 Février

Conférence grand public par Bernard Nordlinger à l’Espace des Sciences, 20h30

Santé et Intelligence Artificielle

Programme

Le colloque se déroule au Couvent des Jacobins du 26 au 28 février 2020.

Wednesday, February 26

13h30 Welcome address

Session 1 – New frontiers in hepatology

  • 14h00
    Human liver organoids to study gene function, tumour modelling and cell division
    Benedetta Artegiani
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Utrecht, the Netherlands
  • 14h35
    New frontiers in liver development: current questions on bile duct morphogenesis
    Frédéric Lemaigre
    Université Catholique de Louvain, de Duve Institute, Brussels
  • 15h10
    HiPSC-derived liver organoids exhibit complex polarization and mature functions
    Antonietta Messina, Eléanor Luce, Ulysse Pereira, Cécile Legallais, Anne Dubart-Kupperschmitt
    UMR_S1193 Inserm / Université Paris‐Sud, DHU Hepatinov, Paris‐Saclay, Villejuif ; Université de technologie de Compiègne, Sorbonne Université, Compiègne, France
  • 15h25
    Extracellular vesicles released by hepatocytes exposed to polycyclic aromatic hydrocarbons trigger apoptosis of target hepatocytes via iron
    Nettie van Meteren, Dimitri Gobart, Agnès Burel, Isabelle Gallais, Éric Le Ferrec, Dominique Lagadic-Gossmann, Odile Sergent
    Univ Rennes, Inserm, EHESP, Irset, Plate-forme MRic-TEM, Biosit, Rennes, France

15h40 Coffee break

Session 2 – Metabolism

  • 16h10
    Mitochondrial cholesterol in liver diseases
    José Fernandez-Checa
    Department of Cell Death and Proliferation, Institute of Biomedical Research of Barcelona and Liver Unit, Barcelona
  • 16h45
    NASH, think outside the liver
    Isabelle Leclercq
    Laboratory of Gastroenterology, Université Catholique de Louvain, Brussels
  • 17h20
    Mechanisms of drug-induced hepatic steatosis in the absence of severe mitochondrial dysfunction: investigations with 12 drugs
    Julien Allard, Simon Bucher, Julie Massart, Pierre-Jean Ferron, Dounia Le Guillou, Yoann Daniel, Youenn Launay, Karima Begriche, Annie Borgne-Sanchez, Bernard Fromenty
    INSERM, Univ Rennes, INRAE, Institut NUMECAN, Rennes, France ; HCS Pharma, Loos, France ; MITOLOGICS S.A.S. Hôpital Henri Mondor, Créteil, France
  • 17h35
    The pathogenesis of NAFLD: How replication stress participates to disease progression?
    Romain Donné, Maëva Aïnama, Pierre Cordier, Mounia Herrag, Mira Stadler, Ivan Nemazanyy, Patrick Revy, Philippe Gual, Mathias Heikenwälder, Valérie Paradis, Chantal Desdouets
    Centre de Recherche des Cordeliers, INSERM, Sorbonne Université ; UMR 1163, Institut Imagine ; Institut Necker Enfants Malades, Université Paris Descartes ; Mediterranean Center for Molecular Medicine C3M, Nice ; German Cancer Research Center,Heidelberg, Germany ; INSERM U773, Centre de Recherche Biomédicale Bichat‐Beaujon, Clichy, France
  • 17h50
    Imbalance between hepatocyte and macrophage iron distribution highlights the singularity of aceruloplasminemia in a new knockout rat model.
    Moussa Kenawi, Emmanuel Rouger, François Robin, Patricia Leroyer, Marie‐Laure Island, Séverine Remy, Ignacio Anegon, Pierre Brissot, Martine Ropert, Thibault Cavey, Olivier Loréal
    INSERM, University of Rennes, INRAE, Institut NUMECAN, Rennes, France; INSERM UMR 1064‐CRTI, TRIP facility, Nantes, France
  • 18h05
    Role of fatty acids in hepatic cytochrome P450 2 E1 induction: involvement in the pathogenesis of non-alcoholic steatohepatitis (NASH) related to obesity.
    Clémence Penhoat, Cassandra Rayer, Matthieu Franc, Bernard Fromenty, Karima Begriche
    Univ Rennes, Inserm, Inrae, Institut NuMeCan, Rennes, France.
  • 18h20
    Lkb1 is a suppressor of the amino acid-driven hepatic gluconeogenic
    Pierre-Alexandre Just, Sara Charawi, Raphaël Denis, Mathilde Savall, Marjorie Leduc, Jean-Pascal De Bandt, François Guillonneau, Serge Luquet,Pascale Bossard, Christine Perret
    INSERM, U1016, Institut Cochin ; CNRS, UMR 8104, Université Paris Descartes ; BFA, Université Paris Diderot, CNRS UMR 8251, Plateforme « Exploration Physiologique Fonctionnelle » EPF ; Plateforme Protéomique de l’Université Paris Descartes (3P5) ; Inserm, UMR-1162, Functional Genomics of Solid Tumors, Univ Paris Descartes, Univ Paris Diderot, Univ Paris 13, France

18h40 End of the day


Thursday, February 27

Session 3 – Tissue repair

  • 08h30
    Using single cell transcriptomics to understand the cellular and molecular mechanisms of liver fibrosis and repair
    Neil Henderson
    Wellcome Trust Senior Research Fellow in Clinical Science, Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh
  • 09h05
    A biliary window on liver regeneration
    Thierry Tordjmann
    INSERM U-1174, Paris-Sud University, Orsay
  • 09h40
    Staufen-1-mediated translational induction of netrin-1 upon hepatic inflammation
    Romain Barnault, Maud Michelet, Anna-Rita Redavid, Ievgeniia Chicherova, Federica Grazia Centonze, Hesso Farhan, Benjamin Gibert, Patrick Mehlen, Fabien Zoulim, Romain Parent
    Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR5286, Centre anticancéreux Léon Bérard, Université de Lyon, Lyon, France ; Department of Molecular Medicine, University of Oslo, Oslo, Norway.
  • 09h55
    Induced pluripotent stem cell-derived human cholangiocytes
    Eléanor Luce, Anne Dubart-Kupperschmitt
    INSERM/Université Paris-Saclay ; FHU Hépatinov, Villejuif, France

10h10 Coffee break

Session 4 – Cancerology 1

  • 10h35
    Metabolic reprograming of hepatocellular carcinomas
    Pascale Bossard
    INSERM U-1016, Institut Cochin, Paris
  • 11h10
    Deciphering the dual role of ß-catenin in hepatocellular carcinoma
    Violaine Moreau
    INSERM U-1053, University of Bordeaux
    11h45
    TFOX, a novel TGFβ target gene, promotes epithelial to mesenchymal transition and is associated with poor prognosis in human hepatocellular carcinoma
    Kevin Bévant, Gaëlle Angenard, Stefano Caruso, Matthis Desoteux, Corentin Louis, David Gilot, Jessica Zucman-Rossi, Cédric Coulouarn
    Inserm UMR124 NuMeCan, Univ Rennes, Rennes ; Centre de Recherche des Cordeliers, Sorbonne Universités, Inserm, Paris ; Functional Genomics of Solid Tumors, USPC, Université Paris Descartes, Université Paris Diderot, Université Paris 13, Labex Immuno-Oncology, équipe labellisée Ligue Contre le Cancer, Paris, France ; Univ Rennes, CNRS, IGDR [(Institut de génétique et développement de Rennes)]-UMR 6290, ARC Labelled team, Rennes, France 12h00
    Plasticity of hepatocellular carcinoma cells across tumor progression leads to metabolic reprogramming and chemoresistance.
    Daniel Yoann, Savary Camille, Petitjean Kilian, Rauch Claudine, Catheline Daniel, Allard Julien, Frenot Brigitte, Burel Agnès, Bendavid Claude, Rioux Vincent, Musso Orlando, Fromenty Bernard, Cabillic Florian, Corlu Anne
    Inserm, Univ Rennes, INRAE, NuMeCan Institute, CHU Rennes, Rennes, France

12h15 Lunch and Poster session (authors in attendance)

Session 5 – Cancerology 2beigene

  • 14h00
    Systemic therapy of cholangiocarcinoma : “to lump or to split”
    Juan Valle
    Department of Medical Oncology, Division of Cancer Sciences, University of Manchester, Manchester
  • 14h35
    Pathomolecular classification of Hepatocellular Carcinomas
    Valérie Paradis
    Pathology Department, Beaujon Hospital, Clichy
  • 15h10
    Proteomic profiling for clinical diagnosis of Hepatocellular Adenomas
    Cyril Dourthe, Sylvaine Di Tommaso, Jean-William Dupuy, Alexandre Brochard, Jean-Frédéric Blanc, Charles Balabaud, Paulette Bioulac-Sage, Frédéric Saltel, Anne-Aurélie Raymond
    Univ.Bordeaux, INSERM, UMR1053, BaRITOn Bordeaux Research in Translational Oncology ; Plateforme Oncoprot, TBM-Core US 005 ; Plateforme Protéome, Centre de Génomique Fonctionnelle ; INSERM, U1215, Neurocentre Magendie ; CHU Bordeaux Department of Hepatology and Oncology, INSERM CIC1401, Bordeaux, France
  • 15h25
    Role of catecholamines on hepatic cell plasticity in hepatocellular carcinoma
    Elise Lelou, Claudine Rauch, Hélène Dubois-Pot-Schneider, Nicolas Nesseler, Anne Corlu,Caroline Aninat
    INSERM U1241, NuMeCan, Univ Rennes,INRAE, CHU Rennes, Rennes, France

15h40 Coffee break and Poster session

  • 16h00
    CHIEF : an update
    Julien Edeline
    Department of Medical Oncology, Centre Eugene Marquis, INSERM U1241, Institut NUMECAN, Univ Rennes, France
  • 16h10
    HCC risk stratification in 2020: strengths of French prospective cohorts
    Pierre Nahon
    Liver Department, Jean Verdier Hospital, Bondy
  • 16h45
    Deleting in vivo ß-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or mesenchymal hepatoblastoma similarly to Apc loss-of-function
    R. Loesch, S. Caruso, S. Picard, A. Gougelet, C. Godard, J. Zucman-Rossi, M. Taketo, S. Colnot
    Centre de recherche des Cordeliers, Université Paris Descartes, Paris, France ; MD Anderson Cancer Center, The University of Texas, Houston, USA
  • 17h00
    TGF-beta-associated circular RNAs in cholangiocarcinoma: mechanisms and biomarkers
    Corentin Louis, Matthis Desoteux, Gaëlle Angenard, Julien Edeline, Cédric Coulouarn
    Inserm, Univ Rennes, NuMeCan, Department of Medical Oncology, Centre Eugene Marquis, Rennes, France.
  • 17h15
    Oncofetal Gene Expression is a Sign of Cell Plasticity toward an Aggressive, Cancer-Stem-Cell-Enriched Subclass of Human Hepatocellular Carcinomas
    Romain Désert, Lise Desquilles, Marie Sicard, Stéphanie Renaud, Natalia Nieto, Orlando Musso
    INSERM, Univ Rennes, INRAE, Institut NUMECAN, Rennes, France ; Department of Pathology, Department of Medicine, University of Illinois at Chicago, IL, USA
  • 17h30
    Challenging the antioxidant protection of β-catenin activated hepatocellular carcinomas
    Mathilde Savall, Nadia Senni, Christine Perret, Pascale Bossard
    Institut Cochin, Development Reproduction Cancer Department, Paris, France
  • 17h45
    Fibroblast growth factor 19 promotes tumorigenesis in genetically defined immunocompetent HCC models
    José Ursic-Bedoya, Carine Chavey, Lucy Meunier, Anthony Lozano, Benjamin Rivière, Eric Assenat, Urszula Hibner, Damien Grégoire
    Institut de Génétique Moléculaire de Montpellier, Department of hepatogastroenterology, Hepatology and Liver Transplantation Unit, Department of Pathology, Saint Eloi Hospital, University of Montpellier, CNRS, Montpellier, France
  • 18h00
    Divergent mutation spectrum singles out Hepatocellular Carcinoma developed in Peruvian Patients
    Juan Pablo Cerapio, Agnès Marchio, Eloy Ruiz, Luis Cano, Enzo Leoni, Sandro Casavilca, Eric Deharo, Anne Dejean, Stéphane Bertani, Pascal Pineau
    Institut Pasteur, Unité “Organisation Nucléaire et Oncogenèse”, INSERM U993 ; Sorbonne Universités, UPMC Université Paris 06, U 1241 NUMECAN, Rennes, Paris, France ; Instituto Nacional de Enfermedades Neoplásicas, Departamento de Cirugía en Abdomen ; Instituto Nacional de Enfermedades Neoplásicas, Departamento de Patologia, Banco de Tejidos Tumorales, Lima, Peru ; Hôpital Cochin, Service d’Anatomie et Cytologie Pathologiques, Paris, France ; Université de Toulouse, UPS, UMR152 PHARMADEV, IRD, Université Toulouse 3, Toulouse, France

18h15 End of the day

19h30 Dinner Le Piccadilly, place de la Mairie


Friday, February 28

Session 6 – Virology

  • 09h00
    Single Cell RNA Seq to understand the biology of virus-induced hepatocellular carcinoma
    Thomas Baumert
    INSERM U-1110, HEPSYS, University of Strasbourg
  • 09h35
    Toward the development of a novel innate-immune stimulators against HBV/HDV infections
    David Durantel
    INSERM U-1052, Cancer Research Center of Lyon, Lyon
  • 10h10
    Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription
    Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Océane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddary, Laura Belloni, Mirjam B. Zeisel, Massimo Levrero, Francesca Guerrieri
    Center for Life Nano Science, Istituto Italiano di Tecnologia ; Unit of Nonlinear Physics and Mathematical Modeling, Department of Engineering, Università Campus Bio-Medico, Roma, Italy ; Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon (CRCL), Lyon, France ; Department of Physics and Chemistry – Emilio Segre’, University of Palermo, Palermo, Italy ; Department of Internal Medicine – DMISM, Sapienza University, Rome, Italy

10h25 Coffee break

Session 7 – New opportunities and practices in hepatology roche

  • 10h50
    Innovations in treatment of liver tumors with internal radiotherapy
    Etienne Garin
    Centre de Lutte contre le Cancer ‘’Eugène Marquis’’, INSERM U1241, Institut NUMECAN, Univ Rennes, France
  • 11h25
    Immunotherapy of hepatocellular carcinomas
    Julien Edeline
    Department of Medical Oncology, Centre Eugene Marquis, INSERM U1241, Institut NUMECAN, Univ Rennes, France
  • 12h00
    Functional rescue of an ABCB11 mutant by ivacaftor: a new targeted pharmacotherapy approach in bile salt export pump deficiency
    Elodie Mareux, Martine Lapalus, Rachida Amzal, Marion Almes, Tounsia Aït Slimane, Jean-Louis Delaunay, Pauline Adnot, Mauricette Collado-Hilly, Anne Davit Spraul, Isabelle Callebaut, Emmanuel Gonzales, Emmanuel Jacquemin
    University of Paris-Sud/Paris-Saclay, INSERM, UMR_S 1193, Hepatinov, Orsay ; Paediatric Hepatology & Paediatric Liver Transplant Department, Reference Center for Rare Paediatric Liver Diseases, Univ Paris Sud/Paris-Saclay, CHU Bicêtre, Le Kremlin-Bicêtre ; Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), UMR_S 938, Institute of Cardiometabolism and Nutrition (ICAN) ; CHU Bicêtre, Biochemistry Unit, Le Kremlin-Bicêtre, France ; Sorbonne Université, Muséum National d’Histoire Naturelle, UMR CNRS 7590, IMPMC, 75005 Paris, France
  • 12h15
    Identification of a proteomic signature predicting response to sorafenib in advanced hepatocellular carcinoma
    Caroline Toulouse, Mélanie Moreau, Sylvaine Di Tommaso, Nathalie Allain-Courtois, Jean-William Dupuy, Brigitte Le Bail, Paulette Bioulac-Sage, Jean-Frédéric Blanc, Anne-Aurélie Raymond, Frédéric Saltel
    Univ.Bordeaux, INSERM, UMR1053, BaRITOn Bordeaux Research in Translational Oncology ; CHU Bordeaux Department of Hepatology and Oncology, INSERM CIC1401 ; Plateforme Oncoprot, TBM-Core US 005 ; Plateforme Protéome, Centre de Génomique Fonctionnelle ; CHU Bordeaux Department of Pathology, Bordeaux, France
  • 12h30
    Metallomic profiles in patients with non-cirrhotic liver hepatocellular carcinoma emphasizes the link between metals and liver carcinogenic process.
    Luis Cano, Stéphane Bertani, Marie-Laure Island, Martine Ropert, Bruno Turlin, Olivier Loréal
    INSERM, Univ Rennes, INRAE, UMR1241, CHU de Rennes, Institut NuMeCan, Plateforme AEM2, Rennes ; Université de Toulouse, IRD, UPS, UMR 152 PHARMADEV, Toulouse.
  • 12h45
    HCC emergence in diabetic mice with NASH depends on high-fat diet and is delayed in liver exhibiting an active immune response
    Mélanie Simoes Eugénio, Muhammad Farooq, Sarah Dion, Christelle Devisme, Céline Raguenes-Nicol, Claire Piquet-Pellorce, Michel Samson, Marie-Thérèse Dimanche-Boitrel, Jacques Le Seyec
    Univ Rennes, Inserm, EHESP, Irset, UMR_S 1085, Rennes, France ; Department of Clinical Sciences, College of Veterinary and Animal Sciences, Jhang, Pakistan.

afef Awards : Oral Presentation and Poster

Concluding remarks, end of the meeting

 

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